Progress in Study on Diagnostic Value of Plasma SEPT9 Gene Methylation for Colorectal Cancer
10.3969/j.issn.1008-7125.2015.09.011
- VernacularTitle:血浆 SEPT9基因甲基化对结直肠癌诊断价值的研究进展
- Author:
Lu ZHUANG
;
Zhaoshen LI
- Publication Type:Journal Article
- Keywords:
Colorectal Neoplasms;
Oncogenes;
DNA Methylation;
Tumor Markers,Biological;
Early Diagnosis
- From:
Chinese Journal of Gastroenterology
2015;(9):556-559
- CountryChina
- Language:Chinese
-
Abstract:
Screening and diagnosis of early colorectal cancer(CRC)can reduce CRC mortality and improve overall survival. Currently,the major screening methods for early CRC include fecal occult blood test(FOBT)and colonoscopy. FOBT exhibits low sensitivity with high false positive rate,while the gold standard -- colonoscopy is invasive and with low compliance. Therefore,a convenient and effective screening and diagnostic method for early CRC is urgently needed. Plasma SEPT9 gene methylation assay is a new non-invasive screening and diagnostic method for early CRC used clinically in recent years,it exhibits high accuracy,and is convenient for mass screening and diagnosis of early CRC. This article reviewed the research progress and diagnostic value of plasma SEPT9 gene methylation assay for CRC.
