Role of microRNA in Regulation of Hepatic Stellate Cell Biological Behavior in Liver Fibrogenesis
10.3969/j.issn.1008-7125.2015.09.013
- VernacularTitle:microRNA 调控肝星状细胞生物学行为在肝纤维化形成中的作用
- Author:
Huili WANG
;
Jinman ZHAO
- Publication Type:Journal Article
- Keywords:
Liver Fibrosis;
Hepatic Stellate Cells;
MicroRNAs;
Epithelial-Mesenchymal Transition
- From:
Chinese Journal of Gastroenterology
2015;(9):563-566
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is a repair response to chronic liver injury caused by liver metabolic disorders due to many injury factors. Hepatic stellate cell(HSC)activation and proliferation play an important role in the pathogenesis of liver fibrosis. In recent years,studies showed that microRNAs(miRNA)are involved in signal transduction pathways related with HSC activation and proliferation. This article reviewed the role of miRNA in regulation of HSC biological behavior in liver fibrogenesis.
