Abnormal percentage of memory B cells in tonsils and peripheral blood in clinical progression of IgA nephropathy
10.3969/j.issn.1671-167X.2015.05.004
- VernacularTitle:腭扁桃体及外周血中记忆B细胞在IgA肾病临床进展中的异常表达
- Author:
Gang WU
;
Youming PENG
;
Daoliang XU
;
Changhua LIU
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis,IGA;
B-lymphocytes;
Tonsillectomy
- From:
Journal of Peking University(Health Sciences)
2015;(5):749-753
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe an abnormal expression of humoral immune response induced by memory B cells in tonsils and peripheral blood of patients with IgA nephropathy ( IgAN) , the variation of memory B cells after tonsillectomy , and to discover the role of tonsillectomy in IgAN .Methods: In the study , 28 patients were diagnosed as IgAN via renal biopsy , and 27 patients suffering from chronic ton-sillitis without nephritis and 10 normal human beings were selected as controls .The expression of memory B cells in the tonsils and peripheral blood was tested by flow cytometry , and the same method was used to test the variation of the expression of memory B cells in peripheral blood of patients with IgAN after tonsil -lectomy.Results:In this study , higher percentages of memory B cells were observed in tonsil and pe-ripheral blood of IgAN patients, which were 5.72%±5.26%, 4.92%±5.10%.After tonsillectomy, the percentage of memory B cells was 1 .10%±0 .65%, lower than that before tonsillectomy ( P <0.05).Meanwhile, in tonsils and peripheral blood , the percentage of memory B cells varied with the variation of the urinary findings of the IgAN patients .Conclusion:The percentage of memory B cell in tonsils and peripheral blood could predict disease progression of IgAN to a certain extent .
