Evaluation of vascular function in patients with Fabry disease
10.3969/j.issn.1671-167X.2015.05.012
- VernacularTitle:法布里病的在体血管功能评价
- Author:
Qian GAO
;
Qing PENG
;
Jing CHEN
;
Wei ZHANG
;
Zhaoxia WANG
;
Yun YUAN
;
Yuehuan ZUO
;
Jing LIU
- Publication Type:Journal Article
- Keywords:
Fabry disease;
Endothelial cells;
Blood flow velocity;
Brachial artery;
Vasodilation
- From:
Journal of Peking University(Health Sciences)
2015;(5):796-799
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the endothelial functions and autoregulation capacity of cerebral blood flow in patients with Fabry disease .Methods:Brachial artery vasodilation was assessed in 8 pa-tients with Fabry disease and 14 healthy controls by means of flow-mediated dilation ( FMD) and Nitro-glycerin-mediated dilation ( NMD) .Cerebrovascular reactivity was calculated in terms of breath-holding index ( BHI) and vascular motor reactivity ( VMR) by TCD-CO2 test in 4 patients and 14 healthy con-trols.Results:Compared with the controls , brachial artery vasodilation experiment showed no difference (the patients:FMD 15.94%±5.03% and NMD 23.92%±7.23%, the controls: FMD 14.57%± 5 .84% and NMD 22 .64%±6 .96%) , there was no relationship between FMD or NMD and the age , course of disease , MSSI or enzyme activity .In respect of cerebrovascular autoregulation capacity , there was no difference in anterior circulation , while cerebrovascular reactivity tended to be impaired in posteri-or circulation .Conclusion:Endothelial function showed no decline in patients with Fabry disease , but cerebrovascular autoregulation capacity tended to be impaired in posterior circulation .
