Analysis of serum IgG titers to Aggregatibacter actinomycetemcomitans serotype c in aggressive periodontitis patients
10.3969/j.issn.1671-167X.2015.05.017
- VernacularTitle:侵袭性牙周炎患者抗伴放线聚集杆菌血清c型IgG滴度分析
- Author:
Xianghui FENG
;
Li ZHANG
;
Li XU
;
Huanxin MENG
;
Zhibin CHEN
;
Dong SHI
;
Ruifang LU
- Publication Type:Journal Article
- Keywords:
Aggressive periodontitis;
Aggregatibacter actinomycetemcomitans;
Serogroup;
Immuno-globulin G
- From:
Journal of Peking University(Health Sciences)
2015;(5):820-824
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the serum IgG titers to Aggregatibacter actinomycetemcomitans ( Aa ) and associated factors in patients with aggressive periodontitis (AgP).Methods:Venous blood samples were collected from 62 AgP patients and 45 periodontal healthy controls , unstimulated whole saliva and pooled subgingival plaque samples of AgP patients were also collected for the detection of Aa ( PCR method) .Serum IgG titers to Aa serotype c were measured by enzyme-linked immunosorbnent assay ( ELISA) .Results:The detection rates of serum IgG to Aa serotype c in the AgP patients and the healthy controls were both 100%.The AgP patients exhibited significantly higher IgG titers to Aa serotype c than the healthy controls (11.1 ±1.9 vs.9.1 ±1.8, P<0.01).There was no significant difference in serum IgG levels to Aa serotype c and in the prevalence of high-responding patients to Aa serotype c between the incisor-first molar type AgP patients and generalized AgP patients .Serum IgG titers to Aa serotype c in the Aa-positive AgP patients ( the patients who were Aa-positive in subgingival plaque or saliva ) were sig-nificantly higher than those of the Aa-negative patients (11.9 ±1.3 vs.10.7 ±2.1, P<0.05).Con-clusion:Serotype c was the main serotype of Aa in Chinese patients with AgP .Serum IgG responses in generalized AgP patients were comparable to those in incisor-first molar type AgP patients .
