Comparative Nerve Distribution of the Pylorus in Infantile Hypertrophic Pyloric Stenosis.
- Author:
Gang Do KIM
1
;
Dae Hyun JOO
;
Yong Oon YOO
;
Sung Hwan PARK
;
Ki Ho PARK
;
Jae Bok PARK
Author Information
1. Department of Surgery, School of Medicine, Catholic University of Daegu, Daegu, Korea.
- Publication Type:Original Article
- Keywords:
Infantile hypertrophic pyloric stenosis;
Neural cell adhesion molecule;
Nerve distribution
- MeSH:
Abdomen;
Cell Adhesion;
Humans;
Muscle Cells;
Muscle, Smooth;
Myenteric Plexus;
Nerve Fibers;
Neural Cell Adhesion Molecules;
Olea;
Pyloric Stenosis, Hypertrophic*;
Pylorus*;
Vomiting
- From:Journal of the Korean Association of Pediatric Surgeons
2002;8(1):23-27
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Infantile hypertrophic pyloric stenosis (IHPS) a common childhood disorders characterized by nonbilious projectile vomiting, an olive shaped mass in the right upper quadrant of the abdomen and visible gastric peristaltic wave in the upper abdomen. Its etiology and pathogenesis are not clear but abnormal nerve distribution of the pylorus has been postulated2-6. We performed immunocytochemical staning to the pyloric muscle from 10 IHPS and 3 controls patients, utilizing specific monoclonal antibody to NCAM(neural cell adhesion molecule). In IHPS patients, the number of NCAM protein immunoreactive nerve fibers were less than that in normal subjects. Auerbach myenteric plexuse was well developed and interbundle nerve plexuse was present but nerve fibers supplying individual muscle cells in smooth muscle bundles were poorly developed. These results indicate reduction of innervation in smooth muscles in IHPS patients that possibly contributes to the pathogenesis of IHPS.
