Comparison of Effect on Antioxidative Stress Between Benezepril and Tranilast in Diabetic Nephropathy Rat
10.3870/j.issn.1004-0781.2015.10.003
- VernacularTitle:贝那普利和曲尼司特抗糖尿病肾病氧化应激效应比较?
- Author:
Xiaohui WANG
;
Xin ZHANG
;
Yong HE
;
Qingping PENG
;
Guosheng YANG
;
Mingmei LI
;
Duan LIU
;
Changjun MU
- Publication Type:Journal Article
- Keywords:
Angiotensin converting enzyme inhibitors;
Tranilast;
Benazepril;
Diabetic nephropathy;
Thioredoxin;
Antioxidative stress
- From:
Herald of Medicine
2015;(10):1276-1280
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate ACEI ( benazepril ) and tranilast exert renoprotective properties in diabetic nephropathy( DN) through the inhibition of thioredoxin( Trx) . Methods Forty male SD rats were randomly divided into normal control group,model control group,tranilast group and benazepril group (n=10 each).Normal control group was fed with normal diet. Other groups were fed with high-glucose high-fat diet to make DN models. Rats in model control, tranilast, and benazepril groups were fed with normal diet,400 mg??kg-1??d-1 tranilast plus normal diet,and 10 mg??kg-1??d-1 benazepril plus normal diet,respectively,via oral gavage for 12 weeks.The 24-hour proteinuria,blood glucose(BG),blood urea nitrogen (BUN),serum creatinine ( Scr) and renal pathology changes were detected. Expression of Trx was measured by Western-blot. Results The 24 h urine protein, BG, BUN, Scr, kidney/body weight, and glomerular sclerosis index were significantly decreased in tranilast group and benazepril group,as compaired with model control group ( P<0.05) ,but there was no statistical difference between the two drug groups (P>0.05).Both tranilast and benazepril can reduce renal pathological changes,and can increase the expression of Trx of DN rats, but benazepril had a more significant effect on increasing Trx expression. Conclusion Both tranilast and benazepril have renoprotective function in DN, and benazepril is more effective than tranilast in delaying the progression of diabetic nephropathy by increasing Trx expression and decreasomg oxidative stress.
