Formulation Optimization of Propranolol Hydrochloride Gels by Central Composite Design-Response Surface Methodology
10.3870/j.issn.1004-0781.2015.10.022
- VernacularTitle:星点设计-效应面法优化盐酸普萘洛尔凝胶处方基质?
- Author:
Liu YANG
;
Aiwu WANG
;
Guangqi XU
;
Ran HUO
- Publication Type:Journal Article
- Keywords:
Propranolol hydrochloride;
Gels;
Central composite design response method;
Chromatography,high performance liquid
- From:
Herald of Medicine
2015;(10):1343-1346
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the matrix formula of propranolol hydrochloride gels. Methods On the basis of single factor experiment, central composite design-response surface method was used to optimize the formula. Addition levels of glycerol (A), PEG-400 (B) and HPMC (C) were evaluated as the independent variables.Eight-hour accumulative penetration amount per unit area measured by HPLC was used as the index. Quadratic polynomial was used to estimate the relationship between the index and the independent variables, and to delineate response surface and overlay contour plots in order to select the optimal formulations.Finally, predicted responses were verified. Results The optimized formula consisted of 18.53% glycerol, 8.54% PEG-400 and 2.35% HPMC.The quadratic polynomial regression model of 8-h accumulative penetration amount per unit area:R1=-7 415. 69+306. 10A+167. 47B+4 820. 59C-8. 26A2-9. 81B2-1 025. 75C2 , and the cumulative transmittance was 49.6%. Conclusion A credible model is established by using central composite design-response surface method and the formula of propranolol hydrochloride gels is optimized and the gel is stable and controllable.
