Research progression of exosome in cardiovascular disease
10.3760/cma.j.issn.1009-9158.2015.07.003
- VernacularTitle:外泌体在心血管疾病中的研究进展
- Author:
Yuan ZHANG
;
Yanwei HU
;
Lei ZHENG
;
Qian WANG
- Publication Type:Journal Article
- Keywords:
Cardiovascular diseases;
Exosomes;
Signal transduction;
Biological markers
- From:
Chinese Journal of Laboratory Medicine
2015;(7):439-441
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are nanosized lipid vesicles released from cells .They are believed to contain proteins, lipids and nucleic acid cargos , and are capable of deliver their cargos to recipient cells , which in turn alter the expression of genes in neighboring cells .An increasing body of evidence indicates that they play a pivotal role in cell-to-cell communication , which is hijacked during various physiological and pathological conditions , such as myocardial damage , angiogenesis , cardiac remodeling and atherogenesis plaque formation .Further research of intercellular communication mediated by exosomes may potentially aid in the possible application of exosomes for biomarker discovery , curative effects , as well as prognosis of cardiovascular diseases , even the use of exosomes as a therapeutic drug delivery system on the basis of the exosome′s ability to target specific cells , and transfer genetic materials.
