Clinical analysis of patients underwent hysterectomy for stage Ⅰ cervical cancer or high grade ;cervical intraepithelial neoplasia with vaginal intraepithelial neoplasia
10.3760/cma.j.issn.0529-567x.2015.07.008
- VernacularTitle:Ⅰ期子宫颈癌和子宫颈上皮内瘤变Ⅲ患者合并阴道上皮内瘤变的临床分析
- Author:
Yue HE
;
Yumei WU
;
Qun ZHAO
;
Bei FAN
;
Xiaohong XU
;
Li ZHU
;
Weiyuan ZHANG
- Publication Type:Journal Article
- Keywords:
Uterine cervical neoplasms;
Cervical intraepithelial neoplasia;
Vaginal neoplasms;
Carcinoma in situ
- From:
Chinese Journal of Obstetrics and Gynecology
2015;(7):516-521
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the necessity of colposcopic directed biopsy to vaginal intraepithelial neoplasia (VAIN) before hysterectomy due to early stage cervical cancer (stage Ⅰ) or high grade cervical intraepithelial neoplasia (CIN). Methods A total of 669 patients who underwent a hysterectomy due to early stage cervical cancer (stage Ⅰ) and CINⅢin Beijing Obstetrics and Gynecology Hospital, Capital Medical University,from January 1, 2009 to December 31, 2013 and followed up, 99 patients with VAIN were enrolled. The clinical data and following up the prognosis were prospectively analyzed retrospectively. Results The occurrence rate of VAIN before and after hysterectomy due to cervical dysplasia was 14.8%(99/669), the occurrence rate and the grade of VAIN showed that significantly increased from CINⅢto cervical cancer stageⅠ(P<0.05);Only 15 patients enrolled had undergone vaginal wall biopsy by colposcopy pre-hysterectomy, including 11 patients who were diagnosed with VAINⅡ-Ⅲand underwent vagina extended resection during the hysterectomy. The 5 year recurrence rate of vaginal stump VAIN after hysterectomy was 12.1%(12/99) and the progression rate was 4.0%(4/99), the recurrent rate was 2.0%(2/99). Conclusions For all the patients who are planning to undergo hysterectomy due to stageⅠcervical cancer and CINⅢ, routine upper side of the vagina wall colposcopic-directed biopsy pre-hysterectomy is strongly recommended. All the patients after hysterectomy due to cervical dysplasia should be followed up regularly within 3 years after hysterectomy.
