The correlation between toll-like receptor 9 gene 2848G/A polymorphism and primary anti-neutrophil ;cytoplasmic antibodies associated small vasculitis
10.3760/cma.j.issn.1007-7480.2015.07.010
- VernacularTitle:Toll样受体92848G/A基因多态性与显微镜下多血管炎的关系
- Author:
Baichan CAO
;
Chao XUE
;
Yunhua LIAO
;
Chunxiang WU
;
Qian PENG
;
Xiaoli WEI
;
Jiang ZHOU
;
Kunpeng BU
- Publication Type:Journal Article
- Keywords:
Polumopphism,single nucleotide;
Antineutrophil cytoplasmic antibodies associated vasculitis;
Toll-like receptor 9
- From:
Chinese Journal of Rheumatology
2015;(7):473-476
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between toll-like receptor 9 (TLR9) gene 2848G/A polymorphism and primary antineutrophil cytoplasmic antibodies (ANCA) associated small vasculitis (AAV). Methods A case-control study was performed among 135 patients diagnosed with AAV and 140 disease-free control and we test the serum biochemical parameter. Polymorphism was analyzed by polymerase chain restricted fragments length polymorphism. As for statistic method, according to the character of data, we performed t-test, chi-square test, Spearman grade related analysis and one-way ANOVA. Results ① The frequencies of AA, GG, GA genotype of TLR9 2848 in AAV patients were 14.07%, 38.52%, and 47.71%, respectively; ② Significant increase in IgM was observed in AA genotype than GG+GA genotype in AAV patients (F=4.561, P<0.05). ③ There was no significant difference between AI and CI in AA, GA and GG genotype in AAV patients (F=2.115, 0.760, P>0.05). Conclusion AA, GA and GG genotypes are detected in TLR9 2848G/A in patients with AAV in Guangxi, without significant correlation with susceptibility to primary AAV in Guangxi.
