Efficacy of pioglitazone combined with insulin in the trea tment of type 2 diabetes mellitus:a meta-analysis of randomized controlled trials

VernacularTitle:吡格列酮联合胰岛素治疗2型糖尿病疗效和安全性的 meta分析
Author: Juan WANG ; Liming CHEN
Publication Type:Journal Article
Keywords: Pioglitazone; Diabetes mellitus,type 2; Meta-analysis; Systematic review; Randomized controlled trial
From: Chinese Journal of Endocrinology and Metabolism 2015;(7):608-610
CountryChina
Language:Chinese
Abstract: The efficacy and safety of pioglitazone in combination with insulin in type 2 diabetic patient were evaluated. CENTRAL, MEDLINE, EMBASE, CBM, CNKI(up to September 2014) were searched by computer. The quality of included randomized controlled trials(RCTs)was assessed according to the Cochrane Collaboration system review, and then meta-analysis was performed using Stata 12. 0. A total of 9 RCTs were included. The results of meta-analyses showed that HbA1C value was lower in the group taking pioglitazone plus insulin than in the group taking insulin without pioglitazone[standard mean difference -0. 48, 95% CI( -0. 55, -0. 40),I2 = 0. 0% ,P = 0. 531], but there were more patients with hypoglycaemic in the pioglitazone plus insulin groups than with insulin without pioglitazone[relative risk 1. 33, 95% CI(1. 21, 1. 46), I2 =75. 4% , P=0. 00].