The bone marrow morphology characteristics and the clinical significance of six patients with severe fever with thrombocytopenia syndrome
10.3760/cma.j.issn.1000-6680.2015.05.003
- VernacularTitle:发热伴血小板减少综合征六例患者骨髓形态学特点及其临床意义
- Author:
Qing WANG
;
Boli LI
;
Baoguo CHEN
;
Huazhong CHEN
;
Yanping SHAO
;
Rui ZHENG
- Publication Type:Journal Article
- Keywords:
Severe fever with throbocytopenia syndrome;
Hemophagocytic lymphohistiocytosis;
Novel bunyavirus;
Bone marrow cell morphology;
Fever;
Thrombocytopenia
- From:
Chinese Journal of Infectious Diseases
2015;(5):266-270
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the bone marrow morphology characteristics in patients with severe fever with thrombocytopenia syndrome (SFTS)and to evaluate the clinical value of bone marrow morphology examination in the diagnosis of SFTS.Methods The bone marrow morphology and clinical data of six newly diagnosed SFTS patients with positive test of novel bunyavirus infection admitted to Taizhou Hospital from July 2011 to November 2014 were retrospectively analyzed.Results The increased ratio of lymphoid and monocytoid histiocytes (0.02 - 0.23 )and hemophagocytic phenomenon were observed in all of the six patients′ bone marrow smears.Two of the six cases were diagnosed with hemophagocytic lymphohistiocytosis (HLH)according to the clinical diagnosis criteria and the remaining four cases were defined as highly suspected HLH.Conclusions The progression of SFTS disease might be closely related with HLH induced by novel bunyavirus infection.Morphology examination of bone marrow smear is beneficial for the early differential diagnosis of SFTS.
