Synchronization likelihood analysis of EEG in Alzheimer's disease

VernacularTitle:阿尔茨海默病脑电信号的同步似然分析
Author: Li LI ; Jingjing CHEN ; Xuyuan ZHENG
Publication Type:Journal Article
Keywords: Alzheimer's disease; Electroencephalogram; Synchronization likelihood; Theta; Alpha
From: International Journal of Biomedical Engineering 2015;(3):152-155
CountryChina
Language:Chinese
Abstract: Objective To study the synchronization of electroencephalogram (EEG) in the patients with Alzheimer's disease (AD). Methods Sixteen-channel EEG was recorded under resting, eyes-closed condition in 8 AD patients and 8 control subjects. After data preprocessing, the synchronization likelihood was measured between pairs of EEG channels for the full band,δband (0.5-4 Hz),θband (4-8 Hz),αband (8-13 Hz) andβband (13-30 Hz) in the AD and control groups. Mean synchronization likelihood values of each frequency band were compared between the two groups. Results At the full band,θband andαband, the mean synchronization likelihood values of the AD group were lower than that of the control group (P<0.05). There was no significant difference in the two groups at theδandβbands (P>0.05). Conclusions The EEG synchronization of AD patients decreases at the full band,θandαbands, suggesting that collaborative information processing ability atθandαbands reduces between different brain regions in the AD patients. The research provides support for further study of the brain functional connectivity characteristics in the AD patients.