Expressions and significances of apoptosis related protein Bcl-2 and Bax in basal-like breast carcinoma

Bingxin Zhang; Xia Zhao; Xihua Jia; Xue Chen; Hong Chen; Qiushuang MA; Jinku Zhang

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Expressions and significances of apoptosis related protein Bcl-2 and Bax in basal-like breast carcinoma

VernacularTitle:凋亡相关蛋白 Bcl-2和 Bax 在基底细胞样乳腺癌中的表达及意义
Author: Bingxin ZHANG ; Xia ZHAO ; Xihua JIA ; Xue CHEN ; Hong CHEN ; Qiushuang MA ; Jinku. ZHANG
Publication Type:Journal Article
Keywords: Breast neoplasms; Proto-oncogene proteins c-bcl-2; Bax
From: Journal of International Oncology 2015;(8):569-572
CountryChina
Language:Chinese
Abstract: Objective To investigate the expressions and significances of Bcl-2 and Bax in basal-like breast carcinoma (BLBC).Methods The expressions of Bcl-2 and Bax were detected in 43 cases of BLBC, 57 cases of non-BLBC and 60 cases of normal breast tissues by immunohistochemistry,and their relationships with physiological and pathological characteristics of patients were analysized.Results The positive rate of Bcl-2 in BLBC was 69.77%,higher than 43.86% in non-BLBC (χ2 =6.647,P =0.01 0)and 21 .67% in normal breast tissues (χ2 =23.831 ,P =0.001 ).The positive rate of Bax in BLBC was 20.93%,lower than 45.61 % in non-BLBC (χ2 =6.564,P =0.01 0)and 76.67% in normal breast tissues (χ2 =31 .270,P =0.001 ).The expressions of Bcl-2 and Bax were correlated with lymphnode metastasis (χ2 =6.927,P =0.008;χ2 =6.203,P =0.01 3)and pTNMstaging of BLBC (χ2 =6.331 ,P =0.01 2;χ2 =5.972,P =0.01 5).There was negative correlation between the expression of Bcl-2 and Bax in BLBC (r = -0.408,P <0.01 0). Conclusion High expression of Bcl-2 and low expression of Bax interact with each other leading to unbalance of cell deferation and apoptosis,resulting in promoting genesis and progress of BLBC.