Progress in impact mechanism of CKIP-1 gene on osteoporosis

VernacularTitle:CKIP-1基因对骨质疏松影响机制的研究进展
Author: Biao HAN ; Yu LI ; Xinchang ZHANG ; Ruixin LI ; Hao LI ; Qiangsong WANG ; Xizheng ZHANG
Publication Type:Journal Article
Keywords: Osteoporosis; CKIP-1; Osteogenic differentiation; BMP signaling pathway; Smad ubiquitination regulatory factor 1
From: International Journal of Biomedical Engineering 2015;(3):176-178
CountryChina
Language:Chinese
Abstract: Osteoporosis (OP) is one of the bone metabolic diseases which seriously harms the health and lives of people. The main cause of OP is that the balance between bone formation and bone absorption, i.e. the balance of the bone remodeling process,is no longer exist. When the bone absorption dominates the process, it will lead to osteopenia, destruction of bone microstructure and increased rate of fracture. Previous studies have shown that casein kinase 2-interacting protein-1 (CKIP-1) plays an important role in the process of bone tissue proliferation and differentiation. It mainly interacts with Smad ubiquitination regulatory factor 1 (Smurf 1) to affect bone metabolism. This review analyzes and summarizes the impact of CKIP-1 on bone tissue osteogenic differentiation direction and its mechanism, which may provide new idea and research orientation for future clinical treatment of osteoporosis.