Roles of miR-200c in tumor diagnosis,metastasis and chemoresistance

VernacularTitle:miR-200c 在肿瘤诊断、转移与耐药中的作用
Author: Ming LI ; Fang DENG ; Ming LI ; Fang DENG
Publication Type:Journal Article
Keywords: MicroRNAs; Neoplasms; Epithelial-mesenchymal transition
From: Journal of International Oncology 2015;(8):602-604
CountryChina
Language:Chinese
Abstract: miR-200c is a member of miR-200 family,and it plays an important role in tumor diagno-sis,metastasis and chemoresistance.miR-200c is identified as a molecular marker and prognostic indicator in cancer screening.It can inhibit epithelial-mesenchymal transition,tumor invasion and metastasis,and increase the chemosensitivity of tumor cells,but the relevant mechanism is still not fully clear.The studies of miR-200c and some factors in regulatory pathway are beneficial to promote its applications in clinical diagnosis.