Nuclear factor-E2 related factor 2 and its effect of cancer prevention
10.3760/cma.j.issn.1673-422X.2015.08.013
- VernacularTitle:核因子 E2相关因子2及其在肿瘤防治中的作用
- Author:
Qing LI
;
Chang XU
;
Qiang LIU
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Universal precautions;
Therapy;
Nuclear factor-E2 related factor 2
- From:
Journal of International Oncology
2015;(8):608-611
- CountryChina
- Language:Chinese
-
Abstract:
Nuclear factor-E2 related factor 2 (Nrf2)can protect the normal cells from the damage of oxidants and electrophones,preventing tumorigenesis and metastasis.However,the abnormal activation of Nrf2 in tumor cells can lead to tumor development.Chemicals acting on Nrf2 pathway include activators and inhibi-tors,Nrf2 inhibitors can increase the chemosensitivity of the tumor,providing a new idea for the drug design of high-efficiency and low-toxicity.
