Study on Chronic Nephrotoxicity of Penthorum chinense

VernacularTitle:赶黄草慢性肾脏毒性研究
Author: Huibo XIE ; Yan TANG ; Qingqing LIU
Publication Type:Journal Article
Keywords: Penthorum chinense; Toxicity,kidney,chronicity
From: Herald of Medicine 2015;(8):1007-1009
CountryChina
Language:Chinese
Abstract: Objective To study chronic nephrotoxicity of Penthorum chinense. To provide a scientific evidence for the development and application of Penthorum chinense in food and drug. Methods 48 SD rats were randomly divided into 4 groups (n=12), 0. 9% sodium chloride solution saline group and three Penthorum chinense treat groups. The Penthorum chinense groups were treated by intragastric administration with 5,10,20 g·kg-1 crude drug once a day for 3 months. The levels of Urea, UA, Cre in serum were detected, and the HE dyeing was chosen to observe the kidney morphology. Results The body weight, nephritic organ quotiety, and the level of Urea, UA, and Cre in each exposure group have no statistically significant difference compared with 0. 9% sodium chloride solution group (P>0. 05). There were no obvious kidney morphology changes in the Penthorum chinense group(F=1. 37,P=0. 268). Conclusion The kidney morphology and function of rat shows no apparente injury after long-term intragastric administration of Penthorum chinense.