Influence of Zhibitai Capsule Combined with Atorvastatin Calcium Tablet on Blood Lipid and Inflammatory Factors in Elder Patients with Dyslipidemia
10.3870/yydb.2015.08.015
- VernacularTitle:脂必泰胶囊与阿托伐他汀钙对老年血脂异常患者血脂和炎症因子的影响
- Author:
Chaoyang WANG
;
Hui CHEN
- Publication Type:Journal Article
- Keywords:
Zhibitai capsule;
Atorvastatin calcium tablet;
Dyslipidemia;
Tumor necrosis factor-alpha;
Interleukin-6
- From:
Herald of Medicine
2015;(8):1047-1049
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of Zhibitai capsule combined with atorvastatin calcium tablet on blood lipid and inflammatory factors in elder patients with dyslipidemia. Methods Sixty-four elder patients with dyslipidemia were randomly divided into control group and treatment group, with 32 cases in each group. Patients of the control group were treated with atorvastatin calcium tablet (10 mg, qd, bedtime administration), while patients in the treatment group were given Zhibitai capsule (240 mg, bid) for 6 weeks. Serum levels of TC, TG, HDL-C, LDL-C, tumor necrosis factor-alpha ( TNF-α) and interleukin-6 (IL-6) were measured before and after treatment. Results After treatment, compared with the control group, TC [(5. 18±0. 57) mmol·L-1 vs. (5. 73±0. 65)mmol·L-1], TG [(1. 52±0. 43) mmol·L-1 vs. (1. 86±0. 48) mmol·L-1], LDL-C [(3. 36±0. 48) mmol·L-1 vs. (3. 85±0. 53)mmol·L-1], TNF-α[(5. 37±2. 21) ng·L-1 vs. (7. 63±2. 59) ng·L-1] and IL-6 [(12.27±2.75) ng·L-1 vs. (15. 63±2. 92) ng·L-1] were significantly decreased (P<0. 01 for all); however, HDL-C [(1. 26±0. 25) mmol·L-1 vs. (1. 13±0. 23) mmol·L-1] was significantly increased in the patients of treatment group (P<0. 05). Conclusion Zhibitai capsule combined with atorvastatin calcium tablet may not only regulate blood lipid level, but also decrease serum tumor necrosis factor-alpha and interleukin-6 so as to inhibit inflammation reaction in elder patients with dyslipidemia.
