Determination of Organic Solvents Residue in Butoconazole Nitrate by Headspace Gas Chromatography

VernacularTitle:顶空气相色谱法测定硝酸布康唑中有机溶剂残留量
Author: Weizhi LIU ; Hankun HU ; Ping LIU ; Wei LIU ; Mi ZHANG ; Baogen ZHENG ; Anni LIU ; Qiang YAN ; Lijuan ZHOU ; Yiming LIU
Publication Type:Journal Article
Keywords: Butoconazole,nitrate; Chromatography,gas; Organic solvent residue
From: Herald of Medicine 2015;(8):1072-1074
CountryChina
Language:Chinese
Abstract: Objective To establish a gas chromatograph method for determing Chloroform, ethyl acetate and N, N-dimethyl formamide in butoconazole nitrate. Methods The samples was detected by Headspace Gas Chromatography. Temperature programming method was adpoted and FID was used as detector. The injector temperature was 200 ℃, and the detector temperature was reach 250 ℃. Nitrogen was used as carrier gas in the experiment. Results In the mentioned chromatographic conditions, Chloroform, ethyl acetate and N, N-dimethyl formamide had good linear relationships in the ranges of 0. 066-0. 588,0. 062-0. 556 and 0. 896-8. 061 μg·mL-1 respectively. The average recoveries were 99. 18%,102. 84% and 98. 71%. RSD were 3. 87%,4. 33% and 3. 71%. Conclusion The detection method is sensitive, accurate, reliable, and can be used as a quality control for butoconazole nitrate.