Progress on anti-angiogenesis treating head and neck squamous cell carcinoma

VernacularTitle:抗血管生成治疗头颈部鳞状细胞癌的研究进展
Author: Yitai SHANG ; Xiaojiang LI
Publication Type:Journal Article
Keywords: Head and neck neoplasms; Angiogenesis inhibitors; Vascular endothelial growth factor A
From: Journal of International Oncology 2015;(8):619-621
CountryChina
Language:Chinese
Abstract: Current treatment strategies for recurrent or metastatic head and neck squamous cell carcino-ma(HNSCC)include palliative chemotherapy and anti-EGFR targeted agents.Angiogenesis is crucial both for the growth of a primary tumor and the development of distant metastasis.Therefore,the angiogenesis factors and their receptors become the targets of therapeutic agents.Current anti-angiogenesis drugs achieve the purpose of treatment mainly by blocking VEGF-VEGFR pathways.And it gets certain effects in clinical trials for the treat-ment of HNSCC.Anti-angiogenesis therapy will provide more choices for treating HNSCC.