6% Hydroxyethyl Starch 130/4 . 0 Injection Combined with Furosemide Injection in Treatment of 55 Cases of Severe Preeclampsia Complicated by Ascites
10.3870/yydb.2015.08.009
- VernacularTitle:6％羟乙基淀粉130/4.0注射液联合呋塞米注射液治疗围生期重度子前期并发腹腔积液55例
- Author:
Ziqiong ZHOU
;
Hongxia GUO
;
Zhiquan LI
;
Chenhong WANG
- Publication Type:Journal Article
- Keywords:
6％ hydroxyl starch 130/4.0;
Furosemide injection;
Human serum albumin;
Preeclampsia,severe;
Ascites
- From:
Herald of Medicine
2015;(8):1024-1028
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effects of different fluid therapies in treating severe preeclampsia complicated by ascites. Methods Between Jan. 2010 and Dec. 2012, patients with severe preeclampsia complicated by ascites in Shenzhen Maternity and Child Healthcare Hospital were included in this study. The treatment group ( n=55 ) were given intravenous drip of 6% hydroxyl starch 130/0. 4 plus furosemide, and the control group (n=52) received intravenous drip of 5%human serum albumin plus furosemide. The mean arterial pressure, respiratory rate, heart rate, oxyhemoglobin saturation, colloid osmotic pressure, hematocrit and the incidence of acute pulmonary edema were observed and compared between the two groups. Results Twenty-four hours after cesarean section, the mean arterial pressure of the treatment group was significantly lower than that of the control group, whereas heart rate and oxyhemoglobin saturation were significantly higher (all P<0. 05). The incidence of acute pulmonary edema of the control group was 17. 3%, while no patient in the treatment group developed acute pulmonary edema. On the 5th day after surgery, the hematocrit and 24 h proteinuria were significantly lower in the treatment group, while colloid osmotic pressure was higher (all P<0. 05). There was no difference in serum albumin level between the two groups (P>0. 05). The average duration of edema after treatment was significantly shorter in the treatment group [(2. 43±0. 37) d versus (3. 74±0. 59) d, P<0. 01]. Conclusion 6% hydroxyl starch 130/4. 0 plus furosemide can effectively elevate the colloid osmotic pressure, resolve edema, improve hypovolemia, sustain oxygen supply to the organs and decrease the complication of pulmonary edema in patients with severe preeclampsia complicated by ascites.
