The mechanism of PDEF inhibit invasion and metastasis of prostate cancer cells with down-reg uLated HIF-1α
10.3969/j.issn.1006-5725.2015.16.005
- VernacularTitle:PEDF下调HIF-1α抑制前列腺癌细胞侵袭转移的机制
- Author:
Yunyi MAO
;
Xianhan JIANG
;
Shengbang YANG
;
Wei LIN
;
Tao ZENG
;
Xinshen ZHU
- Publication Type:Journal Article
- Keywords:
Prostate cancer;
PEDF;
Invasion and metastasis;
HIF-1α
- From:
The Journal of Practical Medicine
2015;31(16):2605-2607
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism that PDEF inhibition the invasion and metastasis of prostate cancer cells by down-reg uLated HIF-1α. Methods PEDF and PBS as the experimental group and control group were add to the c uLture medium of human prostate cancer cell line (PC3), the wound healing and transwell experiment were carried out to observed the ability of invasion and metastasis. And HIF-1α expression was detect by RT-QPCR. ResuLts The res uLts of wound healing and transwell showed that PEDF inhibit the ability of invasion and metastasis of prostate cancer. PEDF down-reg uLated the expression of HIF-1α. Conclusions PEDF inhibit the invasion and metastasis of prostate cancer by down-reg uLated the expression of HIF-1α.It will be the new target of tumor intervention and for the treatment of prostate cancer and other malignant tumors to provide adequate scientific basis and efficient drug candidates.
