A case control study of response to treatment in children with Kawasaki disease on intravenous immunoglobulin
10.3969/j.issn.1006-5725.2015.16.020
- VernacularTitle:川崎病患儿对静脉注射免疫球蛋白治疗反应的病例对照研究
- Author:
Congjun WANG
;
Zhongjing LEI
- Publication Type:Journal Article
- Keywords:
Kawasaki disease;
Intravenous immunoglobulin;
Nonresponse
- From:
The Journal of Practical Medicine
2015;31(16):2651-2654
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features of nonresponsive Kawasaki disease by intravenous immunoglobulin. Methods The clinical data of 163 hospitalized patients of Kawasaki disease from June 2008 to February 2013 were analyzed retrospectively based on the response to high intravenous immunoglobulin (IVIG) therapy. All patients were divided into responsive group and nonresponsive group. The clinical characteristics and biochemical index were compared in two groups. Results The nonresponsive group had more frequently experienced in coronary artery lesion, cervical lymph node enlargement, sterile pyuria and higher levels of neutrophils, CRP, AST, ALT, TBIL and lower levels of albumin, high density lipoprotein, serum sodium concentration than the responsive group (P < 0.05). No differences was found in the age, sex, duration of fever at initial treatment, clinical manifestations complete or incomplete and WBC, CK-MB, PLT, ESR between the two groups (P > 0.05). Conclusion It might be useful in predicting nonresponse to IVIG therapy in children with Kawasaki disease in more frequently experienced coronary artery lesion , cervical lymph node enlargement, sterile pyuria and higher levels of neutrophils, CRP, AST, ALT, LDH, TBIL and lower levels of albumin, high density lipoprotein, serum sodium concentration.
