Significance of the Decreased Expressions of Claudin-1 and ZO-1 Protein as Prognostic Factors in Breast Cancer.
- Author:
Min Joon KIM
1
;
Seong Jae CHA
;
Sung Il PARK
;
Sung Jun PARK
;
In Taik CHANG
;
Beom Gyu KIM
;
Yoo Shin CHOI
;
Tae Jin LEE
Author Information
1. Department of Surhery, College of Medicine, Chung-Ang University, Seoul, Korea. chapluto@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
Breast cancer;
Tight junction;
Claudin-1;
ZO-1
- MeSH:
Breast Neoplasms*;
Breast*;
Carcinogenesis;
Claudin-1*;
Diagnosis;
Estrogens;
Lymph Nodes;
Neoplasm Metastasis;
Risk Factors;
Staphylococcal Protein A*;
Tight Junction Proteins;
Tight Junctions
- From:Journal of the Korean Surgical Society
2007;72(6):453-459
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Tight junction proteins are either over-expressed or suppressed in some cancers. These suppressions of claudin-1 and ZO-1 protein are known to have a significant relationship with the progression of breast cancer. The authors reviewed 42 cases of breast cancer and the staining status of claudin-1 and ZO-1 in order to evaluate Claudin-1 and ZO-1 as clinicopathologic risk factors. METHODS: Immunohistological staining for Claudin-1 and ZO-1 was performed in 42 post-operative pathologically diagnosed infiltrating duct carcinoma specimens. The rate of expression was compared with the clinical record, the pathological diagnosis, the estrogen receptor and progesteron receptor status and the c-erbB2 gene to evaluate the protein expression-breast cancer progression relationship and to investigate the expressions of Claudin-1 and ZO-1 as a prognostic factors in breast cancer. RESULTS: The claudin-1 and ZO-1 expressions were both decreased in all the post-operative specimens. The claudin-1 expressions were significantly decreased 100%, 82.4% and 66.7% as the histologic grade increased. The ZO-1 expressions were shown in 44.8% of the lymph node metastasis negative group and in 7.7% of the lymph node positive group. The expression of ZO-1 decreased by 53.3%, 28.6% and 0%, with statistical significance, as the stage increased. CONCLUSION: The claudin-1 expressions were decreased in the poorly differentiated group, i.e., a high histologic grade, and the ZO-1 expressions were decreased in the lymph node positive group and in the high stage cancer. This shows the possibility of Claudin-1 and ZO-1 as factors for tumorigenesis and progression and as prognostic factors in breast cancer.
