The correlations between the leptin levelsand the prevalence of cervical cancer
10.3969/j.issn.1006-5725.2015.14.037
- VernacularTitle:血清瘦素与宫颈癌发生的相关性
- Author:
Jing ZHANG
;
Mingyue ZHU
- Publication Type:Journal Article
- Keywords:
Uterine cervical neoplasms;
Leptin;
Energy metabolism;
Correlation
- From:
The Journal of Practical Medicine
2015;31(14):2357-2359
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlations between the leptin levels and the prevalence cervical carcinoma. Methods Blood samples were collected from 79 patients with cervical squamous cell carcinoma, 28 patients with cervical intraepithelial neoplasia and 35 healthy donors. The serum leptin concentrations were measured by enzyme linked immunosorbent assay. Meanwhile, tissue samples were obtained from the patients with cervical cancer and cervical intraepithelial neoplasia, Then the expressions oleptin in these tissues were detected by Western blot. Results The level of serum leptin in the patients with cervical cancer was significantly higher than those both in the patients with cervical epithelial tumor and in the healthy control group. the Western blot results also confirmed that the the expressions of leptin in the tumor tissues were atwas the highest level. Conclusion The elevated levels of leptin in serum and tumor tissues of patients with cervical cancer suggest that leptin may be involved in the occurrence and development of cervical cancer.
