The relationships of HGF and c-Met expression with liver metastasis of gastric cancer
10.3969/j.issn.1006-5725.2015.16.015
- VernacularTitle:肝细胞生长因子及其受体c-Met表达与胃癌肝转移的相关性
- Author:
Yanlai SUN
;
Zengjun LI
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Hepatocyte growth factor;
c-Met;
Liver metastase;
Immunohis-tochemistry
- From:
The Journal of Practical Medicine
2015;31(16):2634-2637
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationships of HGF , c-Met expression and clinicopathological factors with liver metastasis of gastric cancer. Methods The tissues of primary tumors and corresponding liver metastasis were collected to detect the expression of HGF and c-Met by immunohistochemistry. Results The positive rates of HGF in the experimental group and the control group were 68% and 60%, respectively , with significant differences between two groups. The positive rates of c-Met of the two groups were 86% and 68%, respectively, with a significant difference between two groups. Lymph node metastasis, high expression of HGF and c-Met were significantly associated with liver metastasis of gastric cancer. The depth of invasion of bowel wall and degree of differentiation were not associated with the liver metastasis of gastric cancer. Conclusion High expressions of HGF and c-Met are closely associated with the liver metastasis mechanism of gastric cancer. The c-Met might be a useful indicator of liver metastasis in patients with gastric cancer.
