Clinical significance of miR-23a expression in lung cancer
10.3969/j.issn.1006-5725.2015.14.017
- VernacularTitle:肺癌患者血清中miR-23a的表达及临床意义
- Author:
Jie LI
;
Yaoling LUO
;
Weiyou LIU
;
Xiaoliang YUAN
;
Qingwen LAI
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
miR-23a;
Lymphatic metastasis;
Drug resistance
- From:
The Journal of Practical Medicine
2015;31(14):2297-2300
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of miR-23a in peripheral blood and analyze its correlation with the clinic-pathological features of patients with lung cancer. Methods The level of miR-23a in peripheral blood of 63 patients with lung cancer and 60 healthy persons was detected using real-time reverse transcription-polymerase chain reaction (RT-PCR), The correlation between miR-23a level and the clinic-pathological features was analyzed. Results The expression level of miR-23a in peripheral blood of patients with lung cancer was significantly higher than that in the healthy persons (P < 0.01).The level of miR-23a was associated with TNM stage (P < 0.05), Lymphatic metastasis (P < 0.01) and the number of chemotherapy (P <0.01). Conclusion The miR-23a level in peripheral blood might be a molecular marker for the diagnosis and prognosis of patients with lung cancer.
