Expression of GDF-15 in chronic mountain sickness rat model and discussion of the relationship with GDF-15 and hepcidin

VernacularTitle:GDF-15在慢性高原病大鼠模型中的表达及其与hepcidind的关系
Author: Hui GENG ; Biqin CHEN
Publication Type:Journal Article
Keywords: Chronic mountain sickness (CMS); GDF-15; hypoxia; erythrocytosis
From: The Journal of Practical Medicine 2015;31(14):2255-2257
CountryChina
Language:Chinese
Abstract: Objective To determine the growth differential factor 15 (GDF-15) in CMS rat model, investigate the significance of GDF-15 in CMS and the relationship between GDF-15 and hepcidin. Methods 32 rats of CMS model were taken as experimental group (EXP), the other 16 rats fed in Xining (CON) were taken as control group. The mRNA and protein expression levels of GDF-15 were detected respectively. Results Compared with that in CON group, the level of mRNA and protein of GDF-15 were significantly higher in EXP group (P<0.01). GDF-15 and EPO had correlation in EXP (r=0.397, P=0.031), but had no correlation with serum hepcidin in EXP (r = -0.224, P = 0.218). Conclusion GDF-15 can promote CMS and represent erythrocytosis, while GDF-15 has no inhibition to the expression of hepcidin.