The effects of recombinant human erythropoietin on thoracic acute spinal cord compressive injury in rats: delayed treatment

VernacularTitle:延迟应用重组人促红细胞生成素治疗大鼠急性挤压性胸脊髓损伤
Author: Xinping YAN ; Liuzhu YANG ; Bo WU ; Zhong CHEN ; Wei TAN
Publication Type:Journal Article
Keywords: Erythropoietin; Delayed treatment; Spinal cord injury; Neuroprotection
From: The Journal of Practical Medicine 2015;31(14):2258-2261
CountryChina
Language:Chinese
Abstract: Objective To investigate the neuroprotection of delayed treatment of thoracic acute spinal cord injury with recombinant human erythropoietin (rhEPO) in rat model of compressive injury. Methods Sixteen adult male Sprague-Dawley rats were randomly divided into two groups: control group (compressive injury group) and experimental group (rhEPO group), In the compressive injury group,the animals recived 0.9% saline treatment at 2 h, day 1 and day 3 after the injury, while in the rhEPO group, rhEPO (3 000 U/kg) was given to rats at 2 h, day 1 and day 3 after the injury. All the rats were observed in 4 days after the injury. The primary outcomes were evaluated by BBB scale, apoptotic index, inflammatory index and electron microscopy. Results Delayed treatment of thoracic acute spinal cord injury with rhEPO could reduce apoptosis, regulate inflammation, improve motor function and promote regeneration of the spinal cord. Conclusion Our study suggests that delayed treatment of thoracic spinal cord compressive injury with rhEPO could exert neuroprotection.