Observation of the Efficacy of Astragalus Injection in Skin of Aging Mice Induced by D-galactose
- VernacularTitle:黄芪注射液对治疗小鼠皮肤衰老的有效性观察
- Author:
Yongmei LIAO
;
Xia XIONG
- Publication Type:Journal Article
- Keywords:
astragalus;
acupoint injection;
D-galactose;
skin aging
- From:
Journal of China Medical University
2015;44(8):721-724
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of acupoint injection of Astragalus on contents of SOD,HYP and MDA in skin of aging mice in-duced by D-galactose. Methods The mice were randomly divided into normal group,model group,Astragalus group,and saline group(n=15). Except for the normal control group,the mice of other groups were treated with continuous subcutaneous injection of D-galactose to establish mice ag-ing model. The Astragalus group mice was injected with 0.01mL Astragalus in Sanzuli acupoint per day,The saline group mice received an injection of same amount of saline. SOD,HYP and MDA changes in the skin tissue and serum were evaluated after 21 days. Results All the index in the skin tissue and serum showed significant difference(P<0.01)between model group mice and normal control group. Compared with model group,SOD activity and MDA content in the skin tissue and serum of the Astragalus group mice were significantly raised,HYP content was significantly reduced (P<0.01). There also were significant differences of these index between the saline group mice and the model group(P<0.05),but the effect was not as good as the Astragalus group mice. Conclusion Acupoint Injection of Astragalus can prevent and protect against skin aging induced by D-galactose.
