Diffusion Tensor Imaging of White Matter in Early Stage of Parkinson''s Disease Based on Tract-based Spatial Statistics Analysis
10.3969/j.issn.1005-5185.2015.08.002
- VernacularTitle:早期帕金森病脑白质特征的扩散张量成像基于纤维束追踪空间统计分析
- Author:
Bingbing LING
;
Yi LU
;
Wei ZHAO
;
Yin MO
;
Juan HU
;
Xuejin SUN
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
Magnetic resonance imaging;
Diffusion tensor imaging;
White matter;
Tract-based spatial statistics
- From:
Chinese Journal of Medical Imaging
2015;23(8):567-572
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To observe white matter structure features of patients with early stage (Hoehn-Yahr 1-2 phase) Parkinson''s disease (PD) by using diffusion tensor imaging (DTI) based on the fiber bundle analysis tract-based spatial statistics (TBSS); and to explore the brain regions of PD patients in which DTI parameters are significantly correlated with unified Parkinson''s disease rating scale (UPDRS) score elevation. Materials and Methods DTI sequence was performed on 27 cases of PD and 30 cases of healthy volunteers. DTI parameters including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were analyzed in all participants by using TBSS technique, and the parameters of two groups were compared. The correlation of clinical UPDRS score with FA value, MD and RD value in the PD group were analyzed.Results Compared with that in the control group, FA values of several brain regions in PD group decreased, while MD and RD value increased (P<0.05). AD showed no obvious change (P>0.05). UPDRS score of PD group was correlated with FA, MD and RD value (P=0.001). The brain regions that showed FA value decreased, MD and RD value increased included corpus callosum, left anterior limb of internal capsule, bilateral anterior radial crown, bilateral superior radial crown and left posterior thalamic radiation (P=0.001).Conclusion There is some changes in white matter structure of the patients with early stage Parkinson''s disease, which may due to demyelination or fiber integrity damaged.
