Relationship Between PET/CT Maximum Standardized Uptake Value, Tumor Markers and Prognosis of Lung Cancer
10.3969/j.issn.1005-5185.2015.08.005
- VernacularTitle:PET/CT最大标准化摄取值及肿瘤标志物与肺癌预后的关系
- Author:
Xiaoyi DUAN
;
Lu BAI
;
Yan LI
;
Weishan ZHANG
;
Xiang LIU
;
Yang LI
;
Youmin GUO
- Publication Type:Journal Article
- Keywords:
Carcinoma;
non-small-cell lung;
Positron-emission tomography;
Tomography;
X-ray computed;
Luorodeoxyglucose F18;
Maximal standardized uptake value;
Tumor markers;
biological;
Prognosis
- From:
Chinese Journal of Medical Imaging
2015;23(8):582-586
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To compare the relationship between the maximum standardized uptake value (SUVmax) of PET/CT imaging and tumor markers in lung cancer, and to provide evidence for the comprehensive assessment of non small cell lung cancer. Materials and Methods The results of PET/CT imaging, serum carcinoembryonic antigen (CEA), cytokeratin-19 fragment antigen 21-1 (CYFRA21-1) and neuronspecific enolase (NSE) of 179 patients with non small cell lung cancer were analyzed, subjects were then divided into different groups according to their clinical features and pathological types, the differences of SUVmax and tumor markers'' level were compared between different groups, and their correlations with tumor histological type, differentiation and the clinical stages were also analyzed.Results SUVmax of the tumor was related with lesion size,≥3 cm tumors'' SUVmax were significantly higher than that of <3 cm tumors (P<0.01), SUVmax and serum NSE level were related with tumor differentiation, and these in low differentiation group were higher than those in high and medium differentiation group (P<0.05,P<0.01). In addition, SUVmax, CEA, CYFRA21-1 and NSE had no correlation with gender, age, pathological type and clinical stage (P>0.05).Conclusion SUVmax and NSE have a certain relationship with tumor differentiation in non small cell lung cancer patients, thus can be used as a reference index for prognosis of indirect prediction of lung cancer.
