Meta Analysis of the Association of Polymorphism in IL-28B Gene and Virological Response to Interferon in HBeAg-positive Chronic Hepatitis B
- VernacularTitle:IL-28B基因多态性与HBeAg阳性的慢性乙型肝炎患者干扰素病毒学应答相关性的meta分析
- Author:
Wei TENG
;
Wei CUI
;
Pei LIU
- Publication Type:Journal Article
- Keywords:
hepatitis B;
antiviral therapy;
IL-28B;
gene polymorphism;
meta analysis
- From:
Journal of China Medical University
2015;44(8):749-752
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between the polymorphism in IL-28B gene and the interferon virological response in HBeAg-posi-tive chronic hepatitis B patients. Methods A literature search was performed on PubMed,web of Science,China Bio Medicine(CBM)and wan-Fang database. The references was screened with the inclusion and exclusion criteria,and then data were extracted and methodological quality of the studies was judged. Statistical analysis was carried out with RevMan 5.3 and STATA 11.0. Results Totally 7 publications were recruited for the study,including 1 345 patients. The meta-analysis showed that there was no significant difference of interferon response between HBeAg-positive chronic hepatitis B patients with rs8099917TG/GG alleles and rs8099917TT alleles (P= 0.20). There was no statistical difference between Rs12979860CC and CT/TT allele for the sustained virological response(P=0.75). Conclusion Our current meta-analysis suggests that there was no correlation of rs8099917,rs12979860 polymorphism in IL-28B with the sustained virological response to interferon in HBeAg-positive chronic hepatitis b.
