The mechanisms of carbapenem resistance inKlebsiella pneumoniae
10.3969/j.issn.1000-3606.2015.10.017
- VernacularTitle:肺炎克雷伯菌耐碳青霉烯类药物的机制
- Author:
Xiaoyu QIAO
;
Qi LU
- Publication Type:Journal Article
- Keywords:
Klebsiella pheumohiae;
carbapenemases;
carbapenem antibiotics;
resistance mechanism
- From:
Journal of Clinical Pediatrics
2015;(10):907-911
- CountryChina
- Language:Chinese
-
Abstract:
Klebsiella pneumoniae is well known as a causative agent of both community and nosocomial infections and is generally believed to be the cause of 10% of the nosocomial infection. Recently, with the widespread using of carbapenem, the isolation of carbapenem-resistant strains has been greatly increased, which bring great dififculties and challenges in clinical treat-ment. In this article, the progresses in the mechanisms of carbapenem, resistance inKlebsiella pneumoniae such as the acquisition of carbapenemases, hyperproduction of AmpC cephalosporinases or extended spectrum beta-lactamases (ESBLs) in combination with loss of the outer membrane protein, eflfux pump system, and bioiflm were reviewed.
