Assessment of a swine model following coronary microembolization:MR characterization and its evolution
10.3969/j.issn.1002-1671.2015.10.036
- VernacularTitle:猪冠状动脉微栓塞模型的 MR 特征及其演变过程分析
- Author:
Hang JIN
;
Hong YUN
;
Jianying MA
;
Zhangwei CHEN
;
Shufu CHANG
;
Shan YANG
;
Mengsu ZENG
- Publication Type:Journal Article
- Keywords:
coronary angiography;
coronary microembolization;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2015;(10):1712-1716
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the MR characterization of coronary microembolization (CME)in an animal model as well as the evolution using MR cardiac cine,first-pass perfusion,and delay enhancement imaging.Methods Coronary microembolization models were established through intracoronary infusion of 120 000 microspheres (42 μm)into the left anterior descending artery in 1 1 pigs. Coronary angiography was performed at baseline and immediately after the injection of microspheres.MR imaging was carried out at baseline,6 hours,and 1 week after microembolization.Then,postmortem evaluation was performed using NBT and HE staining.Re-sults Coronary angiography after the injection of microspheres showed normal-appearing epicardial arteries in all animals.Coronary microembolization caused a significant decline in systolic wall thickening of the microembolized myocardial segments on cine MR ima-ges [from (42.6±2.0)% at baseline to (20.3±2.3)% at 6 hours and (31.5±2.1)% at 1 week after CME;P < 0.001 for both]. First-pass perfusion deficit was visualized at 6 hours after microembolization,and was less pronounced at 1 week.Hyperenhanced myocardium was found on delay enhancement MRI at 6 hours after microembolization in microembolized segments,but was not shown at 1 week. The microinfarcts were detectable microscopically through HE staining but invisible for the naked eye on gross NBT specimen.Con-clusion Coronary microembolization may cause a persistent decline in myocardial contraction and its MR characterization may vary with different stages.A combined use of different cardiac MRI techniques and follow-up examinations may be helpful for evaluating myocardial impairment due to coronary microembolization.
