Curative effect of gamma globulin for the early treatment of severe or almost severe hand -foot -mouth disease
10.3760/cma.j.issn.1008-6706.2015.20.032
- VernacularTitle:早期应用静注丙种免疫球蛋白治疗重症和重症倾向手足口病效果观察
- Author:
Hongbing LI
;
Xianyu BU
;
Bin LI
;
Fengzhi WANG
;
Xiaoqin DU
;
Xuefei MENG
- Publication Type:Journal Article
- Keywords:
Hand -foot -mouth disease;
gamma -globulins;
Treatment outcome
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(20):3142-3144
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the efficacy of gamma globulin in the early treatment of severe or almost severe hand -foot -mouth disease.Methods 80 children with severe or almost severe hand -foot -mouth disease were randomly divided into treatment group and control group by the random number table.The treatment group received the treatment of early gamma globulin,whereas patients in the control group received conventional therapy.The effective rate of the treatment group was higher than that of the control group(95.0%vs 77.5%,χ2 =5.165,P <0.05).The recovery time of body temperature and hemogram,rash and other adverse symptoms disap-peared in the treatment group were significantly shorter than those of the control group[(2.1 ±0.9)d vs (3.0 ± 1.1)d,(1.9 ±0.8)d vs (2.8 ±1.1)d,(4.1 ±1.3)d vs (6.2 ±2.1)d,(2.6 ±0.8)d vs (4.8 ±1.5)d,t =3.934,3.723,5.378,7.357,all P <0.05].Conclusion Early application of gamma globulin is effective and safe in treating severe hand -foot -mouth disease,which can relieve symptoms,control the disease quickly and improve prognosis.
