Effect of montelukast sodium on TGF - 1 level of peripheral blood mononuclear cells from children with mild persistent asthma
10.3760/cma.j.issn.1008-6706.2015.20.033
- VernacularTitle:孟鲁司特钠对哮喘儿童血清生长因子β1表达的影响
- Author:
Jun ZHANG
- Publication Type:Journal Article
- Keywords:
Asthma;
Growth factor beta 1;
Montelukast sodium;
Child
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(20):3145-3148
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect and mechanism of montelukast sodium on transforming growth factorβ1 (TGF -β1 )expression in children with asthma.Methods 80 children with asthma were divided into 2 groups.The control group was treated with common medicine,and the observation group was treated with monte-lukast sodium.The clinical effect of two groups was evaluated.The peripheral eosinophile granulocyte(EOS)count of children was measured before and after treatment.Double antibody sandwich enzyme -linked immunosorbent assay (DAS -ELISA)was used to detect the serum levels of TGF -β1 and leukotriene E4 (LTE4)before and after treatment.Results The total effective rate of montelukast sodium group was 95.0%,remarkable effect in 28 cases, 10 cases were effective,and 2 cases failed.The total effective rate of the control group was 82.5%,23 cases had remarkable effect,effective in 10 cases,ineffective in 7 cases.The effective rate of the montelukast sodium group was statistically higher than the control group(χ2 =4.200,P <0.05).After treatment,the peripheral eosinophil count of patients of two groups significantly decreased than before treatment (control group:χ2 =3.251,P <0.05;observation group:χ2 =3.214,P <0.05).There was significant difference between the two groups(χ2 =3.254,P <0.05).Before treatment,serum levels of TGF -1 showed no statistical difference between the two groups (P >0.05).After treat-ment,the levels of serum TGF -1,LTE4 of the observation group decreased more remarkably when compared with the control group (TGF -β1:t =2.06,P <0.05;LTE4:t =2.14,P <0.05).Conclusion Montelukast sodium has good clinical effect on childhood asthma.It can inhibit the expression of TGF -1 in childhood asthma,and its mechanism may be related to eosinophils and the level of LTE4.
