Different blood purification techniques on serum fibroblast growth factor 23 in maintenance hemodialysis patients
10.3760/cma.j.issn.1008-6706.2015.20.010
- VernacularTitle:不同血液净化方法对维持性血液透析患者血清成纤维细胞生长因子23的影响
- Author:
Zhang LI
;
Ruofu LI
;
Zhangzhang HUANG
;
Haijun YE
;
Kechai WU
- Publication Type:Journal Article
- Keywords:
Maintenance dialysis;
Fibroblast growth factor -23;
Blood purification
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(20):3072-3075
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare different blood purification techniques on serum fibroblast growth factor 23(FGF -23)scavenging effect in patients undergoing maintenance hemodialysis (MHD),in order to choose the best blood purification method for clinical maintenance hemodialysis patients.Methods 60 MHD patients were randomly divided into hemodialysis group (HD),hemodiafiltration group (HDF)and HD +HP group,20 cases in each group. Three groups of patients in the observation 1st start of treatment and observation at the end of the last treatment were detected cacium,phosphorus,FGF -23,intact parathyroid hormone(iPTH).Results After treatment,HD group and HDF group,Ca:t =0.29,P =0.77;P:t =1.65,P =0.11;iPTH:t =16.85,P =0.00;HD group and HD +HP group:Ca:t =0.20,P =0.84;P:t =2.62,P =0.01;iPTH:t =42.64,P =0.00;HDF group and HD +HP group:Ca:t =0.09,P =0.92;P:t =2.18,P =0.04;iPTH:t =31.41,P =0.00.After treatment,FGF -23 in the three groups were decreased significantly than before treatment,and the HD +HP group decreased most significantly(HD group and HDF group,t =4.47,P =0.00;HD group and HD +HP group:t =8.06,P =0.00;HDF group and HD +HP group:t =3.20,P =0.00).Conclusion HD +HP treatment can effectively remove phosphorus maintenance dialysis patients and FGF -23.
