Clinical effect of atorvastatin in treatment of coronary heart disease
10.3760/cma.j.issn.1008-6706.2015.20.022
- VernacularTitle:阿托伐他汀治疗冠心病临床疗效分析
- Author:
Yi XIAO
;
Hongjuan LI
;
Junfang YAN
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Atorvastatin;
Treatment outcome
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(20):3110-3112
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical effect of atorvastatin combined with conventional cardiovascu-lar drugs therapy in treatment of coronary heart disease.Methods 200 patients with coronary heart disease were col-lected.They were randomly divided into the observation group(n =100)and control group(n =100).The observation group was given atorvastatin combined with cardiovascular routine treatment for 1 year,the control group was given cardiovascular routine therapy for 1 year.The clinical effect and serum levels of TC,HDL -C,LDL -C were ana-lyzed.Results After treatment,the total effective rate of the observation group was 95%,which was significantly higher than 75% of the control group (χ2 =16.33,P =0.00 <0.05).According to the gender stratification,the effec-tive rates of the observation group were higher than the control group in men and women (men:96% vs 80%,χ2 =6.35,P =0.04 <0.05,women:94% vs 70%,χ2 =10.08,P =0.00 <0.05).Before treatment,there were no signifi-cant differences between the two group about the serum levels of TC,HDL -C,LDL -C[TC:(6.49 ±0.42)mmol/L vs (6.53 ±0.51)mmol/L,t =1.28,P =0.10 >0.05;HDL -C:(1.35 ±0.23)mmol/L vs (1.29 ±0.32)mmol/L, t =1.51,P =0.15 >0.05;LDL -C:(4.54 ±0.62)mmol/L vs (4.48 ±0.61)mmol/L,t =0.84,P =0.20 >0.05]. After treatment,the serum levels of TC,HDL -C,LDL -C of the observation group were significantly better than those of the control group[TC:(3.39 ±0.31)mmol/L vs (5.78 ±0.64)mmol/L,t =2.36,P =0.02 <0.05;HDL -C:(1.63 ±0.42)mmol/L vs (1.32 ±0.51)mmol/L,t =2.87,P =0.00 <0.05;LDL -C:(2.37 ±0.42)mmol/L vs (3.95 ±0.43)mmol/L,t =2.62,P =0.01 <0.05].Conclusion Atorvastatin can reduce blood fat,improve the prognosis of disease,it is superior to the traditional treatment.
