Influence of trimetazidine combined with atorvastatin on heart function and the BNP level in patients with coronary heart failure
10.3760/cma.j.issn.1008-6706.2015.20.037
- VernacularTitle:曲美他嗪联合阿托伐他汀对冠心病心力衰竭患者心功能及血浆脑钠肽的影响
- Author:
Fan LI
- Publication Type:Journal Article
- Keywords:
Trimetazidine;
Atorvastatin;
Coronary disease;
Heart failure;
Natriuretic peptide,brain
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(20):3158-3160
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of trimetazidine combined with atorvastatin on heart func-tion and the BNP level in patients with cornary heart failure.Methods The clinical data of 400 patients with cornary heart disease were retrospectively analyzed.194 patients in the control group were treated with conventional treatment, 206 patients in the observation group were treated with trimetazidine combined with atorvastatin on the basis of the control group.The treatment effect,cardiac function and BNP level were observed and compared.Results The effec-tive rate of the observation group was 91.26%,which was significantly higer than 76.29% of the control group (χ2 =16.667,P <0.05).After treatment,the cardiac index,stroke volume,cardiac output,left ventricular ejection fraction and BNP level of the two groups were significantly higher than before treatment,and those in the observation group were significantly higher than the control group(t =2.505,2.851,3.308,3.452,all P <0.05).Conclusion Trime-tazidine combined with atorvastatin in treatment of cornary heart failure has good curative effect,it can reduce the serum level of BNP,improve cardiac function significantly,which is of great value for clinical use.
