MYC Rearrangement Involving a Novel Non-immunoglobulin Chromosomal Locus in Precursor B-cell Acute Lymphoblastic Leukemia.
10.3343/alm.2012.32.4.289
- Author:
Ja Young SEO
1
;
Soo Hyun LEE
;
Hee Jin KIM
;
Keon Hee YOO
;
Hong Hoe KOO
;
Yong Gon CHO
;
Sam Im CHOI
;
Sun Hee KIM
Author Information
1. Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. heejinkim@skku.edu
- Publication Type:Case Reports
- Keywords:
Precursor B-cell acute lymphoblastic leukemia;
MYC gene rearrangement;
Non-immunoglobulin partner
- MeSH:
Bone Marrow Cells/pathology;
Child, Preschool;
Chromosomes, Human, Pair 4;
Chromosomes, Human, Pair 8;
Genetic Loci;
Humans;
Immunoglobulins/genetics;
Karyotyping;
Male;
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*genetics/metabolism/pathology;
Proto-Oncogene Proteins c-myc/*genetics;
Recurrence;
Translocation, Genetic
- From:Annals of Laboratory Medicine
2012;32(4):289-293
- CountryRepublic of Korea
- Language:English
-
Abstract:
MYC rearrangement, a characteristic cytogenetic abnormality of Burkitt lymphoma and several subsets of other mature B-cell neoplasms, typically involves an immunoglobulin gene partner. Herein, we describe a case of precursor B-cell lymphoblastic leukemia harboring a MYC rearrangement with a novel non-immunoglobulin partner locus. The patient was a 4-yr-old Korean boy with ALL of the precursor B-cell immunophenotype. At the time of the second relapse, cytogenetic analyses revealed t(4;8)(q31.1;q24.1) as a clonal evolution. The MYC rearrangement was confirmed by FISH analysis. He died 3 months after the second relapse without achieving complete remission. To our knowledge, this is the first report of a case of MYC rearrangement with a non-immunoglobulin partner in precursor B-cell lymphoblastic leukemia.
