A Case of Near-triploidy in Myelodysplastic Syndrome with del(5q) Combined with del(1p) and del(13q).
10.3343/alm.2012.32.4.294
- Author:
Bo Ram KIM
1
;
Ji Eun KIM
;
Kwang Sook WOO
;
Kyeong Hee KIM
;
Jeong Man KIM
;
Suee LEE
;
Lisa G SHAFFER
;
Jin Yeong HAN
Author Information
1. Department of Laboratory Medicine, Dong-A University College of Medicine, Busan, Korea. jyhan@dau.ac.kr
- Publication Type:Case Reports ; Research Support, Non-U.S. Gov't
- Keywords:
Near-triploidy;
Myelodysplastic syndrome;
Array CGH
- MeSH:
Aged;
Bone Marrow Cells/pathology;
*Chromosome Deletion;
Comparative Genomic Hybridization;
Humans;
Karyotyping;
Male;
Myelodysplastic Syndromes/*genetics;
Triploidy
- From:Annals of Laboratory Medicine
2012;32(4):294-297
- CountryRepublic of Korea
- Language:English
-
Abstract:
Numerical and structural chromosomal abnormalities are common in hematological malignancies. Near-triploidy (58-80 chromosomes) is a numerical abnormality observed in 3% of adult cases of acute lymphoblastic leukemia. Near-triploidy is rare in myeloid lineage hematologic malignancies and compared to near-triploidy in lymphoid malignancies, near-triploidy in myeloid malignancies is associated with poor outcomes. Few studies on near-triploidy in myelodysplastic syndrome (MDS) have been reported, and the clinicopathologic significance of this condition is still unclear. Here, we report a novel case of MDS with near-triploidy and multiple structural chromosomal abnormalities: del(5q) combined with del(1p) and del(13q). These abnormalities were detected by cytogenetic analysis with array comparative genomic hybridization (CGH). Our results suggest that array CGH can be a useful tool for detecting chromosomal abnormalities in patients with MDS.
