Mutational profiling in patients with myeloproliferative neoplasms: ready for every-day use in the clinic?
10.3760/cma.j.issn.1009-9921.2015.07.002
- VernacularTitle:骨髓增殖性肿瘤患者的基因突变检测:已进入临床时代?
- Author:
Zhijian XIAO
- Publication Type:Journal Article
- Keywords:
Myeloproliferative neoplasms;
Gene mutation;
Diagnosis;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2015;24(7):388-391
- CountryChina
- Language:Chinese
-
Abstract:
The novel second or next-generation sequencing (NGS) technique enables comprehensive mutational profiling analysis in patients with myeloproliferative neoplasms (MPN).JAK2,MPL and CALR gene mutations are successfully introduced into diagnostic practice,mutations in genes may impact outcomes such as survival and risk of leukemic transformation,therefore,molecular mutation analysis is ready for use in all patients with suspected MPN.
