Acute adverse effects of radiotherapy on HIV-positive patients with malignancy
10.3760/cma.j.issn.0254-5098.2015.09.011
- VernacularTitle:人类免疫缺陷病毒阳性恶性肿瘤患者放射治疗的急性放射性反应观察
- Author:
Xiang DING
;
Shuhui YU
;
Qing LONG
;
Qun XIA
;
Yiqin AI
;
Wenhui LI
;
Jianguo CUI
- Publication Type:Journal Article
- Keywords:
Malignancy;
Radiotherapy;
Human immunodeficiency virus;
Acute adverse effect
- From:
Chinese Journal of Radiological Medicine and Protection
2015;35(9):687-689
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe and evaluate acute toxicities in a series of human immunodeficiency virus (HIV)-positive cancer patients receiving radiation therapy.Methods The study retrospectively reviewed the acute radiation reaction of radiation therapy of 14 HIV seropositive patients diagnosed with carcinoma between Feb 2008 and Dec 2013 at the Yunnan Tumor Hospital during the radiotherapy period and 1 month following treatment.Acute adverse effects were classified according to the site of radiation therapy and analyzed using the Common Terminology Criteria for Adverse Events (CTCAE) version 3.0.Results Seven patients experienced interruptions or delays in treatment,and 2 stopped treatment entirely.The most common acute adverse effects were skin reactions and mucous membrane reactions,including dermatitis,stomatitis or diarrhea.Eight patients had grade 3 acute adverse effects,including 6 patients with grade 3 skin reactions and 2 patients with grade 3 mucosa reactions.Conclusions Radiotherapy is an effective treatment for HIV positive patients with tumors,however it frequently induced severe acute radiation responses.
