Isocitrate dehydrogenase gene mutations in intrahepatic cholangiocarcinoma
10.3760/cma.j.issn.1007-8118.2015.10.021
- VernacularTitle:异柠檬酸脱氢酶基因突变在肝内胆管癌中的作用
- Author:
Jun CHEN
;
Jiong SHI
;
Liang MAO
;
Yudong QIU
- Publication Type:Journal Article
- Keywords:
Isocitrate Dehydrogenase IDH;
2-hydroxyglutarate (2HG);
Gene mutation;
Intrahepatic cholangiocarcinoma
- From:
Chinese Journal of Hepatobiliary Surgery
2015;21(10):715-717
- CountryChina
- Language:Chinese
-
Abstract:
Mutations in isocitrate dehydrogenase are among the most common genetic alterations in intrahepatic cholangiocarcinoma (ICC).Mutant IDH proteins in ICC and other malignancies acquire an abnormal enzymatic activity, allowing the conversion of alpha-ketoglutarate (alphaKG) to 2-hydroxyglutarate (2HG), which inhibits the activity of multiple alphaKG-dependent dioxygenases, and results in alterations in cell differentiation and tumorigenesis.This review will focus on recent advances, which may help understand the function of IDH mutation in intrahepatic cholangiocarcinoma.
