Multidrug resistance mechanism of gallbladder cancer
10.3760/cma.j.issn.1007-8118.2015.10.020
- VernacularTitle:胆囊癌多药耐药的机制
- Author:
Sunwang XU
;
Jian WANG
- Publication Type:Journal Article
- Keywords:
Gallbladder cancer;
Multidrug resistance
- From:
Chinese Journal of Hepatobiliary Surgery
2015;21(10):712-715
- CountryChina
- Language:Chinese
-
Abstract:
Gallbladder cancer is the most common malignancy of biliary tract, ranking the sixth among gastrointestinal tract cancers worldwide.However, the low resectability, dissatisfied chemosensitivity and multidrug resistance of gallbladder cancer are currently the major challenges in the clinical management.The drug resistance has been reported to be a rather complex process, mainly involving drug effiux pump, drug-resistance mediating enzymes, transcription factors, cell autophagy and so on.Investigating the potential multidrug resistance mechanisms in gallbladder cancer and clarifying the related influential factors is the key to improving the chemosensitivity of gallbladder cancer.Slacking or reversing the resistance and enhancing the chemosensitivity could provide new idea for treating gallbladder cancer.
