Correlation between long non-coding RNA in tumor tissues and clinico-pathological characteristics of hepatocellular carcinoma
10.3760/cma.j.issn.1007-8118.2015.09.007
- VernacularTitle:肿瘤组织中长链非编码RNA表达与肝细胞癌临床病理特征的关系
- Author:
Peiyan YE
;
Yunfei LU
;
Qingnian XU
;
Xiaorong CHEN
;
Zongguo YANG
- Publication Type:Journal Article
- Keywords:
Long non-coding RNA;
Hepatocellular carcinoma;
Clinico-pathological characteristics
- From:
Chinese Journal of Hepatobiliary Surgery
2015;21(9):604-607
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between long non-coding RNAs (LncRNA) in tumor tissues and clinico-pathological features of hepatocllular carcinoma (HCC).Methods Using hepatocellular carcinoma gene database GSE36376,we conducted a study on eight LncRNAs which are associated with liver diseases and analyzed the correlation between these LncRNAs and HCC clinico-pathological characteristics.We also evaluated the potential effect of LncRNAs on HCC development.Results H19 was overexpressed in non-tumorous tissues of HCC (P ＜ 0.05),while MEG3,HOXA13,KCNQ1OT1 were all upregulated in tumorous tissues (all P ＜ 0.05).HULC level in HCC tumorous tissues was negatively correlated with AJCC staging,BCLC staging and tumor size (all P ＜ 0.05).UCA1 was positively correlated with BCLC staging (r =0.135,P ＜ 0.05).Univariate analysis and multivariate logistic analyses showed that UCA1 was a risk factor of intrahepatic metastasis of HCC (OR =6.054,95％ CI =1.429 ～ 25.642,P ＜ 0.05); in contrast,HULC overexpression in tumorous tissues played a positive role in HCC tumor size (OR=0.805,95％CI=0.678 ～0.956,P＜0.05).Conclusion HULC in tumorous tissues suppressed HCC proliferation,while UCA1 was a risk factor of HCC aggressiveness.
