Pulsatile delivery pellets:research advances
10.13220/j.cnki.jipr.2015.04.010
- VernacularTitle:脉冲释药微丸的研究进展
- Author:
Hang FENG
;
Ying LI
;
Xingguo MEI
- Publication Type:Journal Article
- Keywords:
pulsatile pellets;
pulsatile delivery system;
chronopharmacology
- From:
Journal of International Pharmaceutical Research
2015;(4):483-487
- CountryChina
- Language:Chinese
-
Abstract:
Under physiological conditions, many vital functions of the body are controlled by transient release of bioactive substances at a specific time and site. Based on the circadian rhythm character of disease and chronotherapeutic conceptions, pulsatile delivery system has been designed to achieve optimal therapeutic effect and reduce the toxic and side-effect. In recent years, more and more studies are focused on the pulsatile multiparticulate drug delivery system. Pulsatile multiparticulate system possesses many benefits, such as no risk of dose dumping, predictable gastric emptying, flexible release patterns and increased bioavailability. Based on these premises, the aim of this review is to summarize the major design methods of pulsatile multiparticulate and the research progress.
